|Other Names||Serpin H1, 47 kDa heat shock protein, Arsenic-transactivated protein 3, AsTP3, Cell proliferation-inducing gene 14 protein, Collagen-binding protein, Colligin, Rheumatoid arthritis-related antigen RA-A47, SERPINH1, CBP1, CBP2, HSP47, SERPINH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7366b was selected from the C-term region of human SERPINH1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CBP1, CBP2, HSP47, SERPINH2|
|Function||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.|
|Cellular Location||Endoplasmic reticulum lumen.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.
Araki,K., Br. J. Cancer 101 (3), 492-497 (2009)Katagata,Y., J. Dermatol. Sci. 49 (1), 33-38 (2008)
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