|Other Names||Pro-cathepsin H, Cathepsin H mini chain, Cathepsin H, Cathepsin H heavy chain, Cathepsin H light chain, CTSH, CPSB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7380a was selected from the N-term region of human CTSH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Important for the overall degradation of proteins in lysosomes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of its gene has been correlated with malignant progression of prostate tumors.
Bunatova,K., Int. J. Biol. Markers 24 (1), 47-51 (2009)Decock,J., Int. J. Biol. Markers 23 (3), 161-168 (2008)
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