|Other Names||Calcium homeostasis modulator protein 1, Protein FAM26C, CALHM1, FAM26C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7399a was selected from the N-term region of human CALHM1/FAM26C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Colocalizes with HSPA5 at the endoplasmic reticulum|
|Tissue Location||Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells Specifically expressed in circumvallate taste bud cells|
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Provided below are standard protocols that you may find useful for product applications.
CALHM1 is a cerebral Ca(2+) channel that controls processing of amyloid-beta (A-beta) precursor protein.
Beecham,G.W., Ann. Hum. Genet. 73 (PT 3), 379-381 (2009)Sleegers,K., Hum. Mutat. 30 (4), E570-E574 (2009)Bertram,L., Cell 135 (6), 993-994 (2008)Dreses-Werringloer,U., Cell 133 (7), 1149-1161 (2008)
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