|Other Names||Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP, CRHBP, CRFBP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7431b was selected from the C-term region of human CRHBP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|
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Provided below are standard protocols that you may find useful for product applications.
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein (CRHBP) which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Behan D.P., Potter E., Lewis K.A.Genomics 16:63-68(1993)Fischer W.H., Behan D.P., Park M.J. Biol. Chem. 269:4313-4316(1994)
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