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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CRSP8 Antibody (Center) Blocking Peptide   

CRSP8 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6P2C8
Clone Names 81006055
Peptide ID 81006055
Additional Information
Gene ID 9442
Other Names Mediator of RNA polymerase II transcription subunit 27, Cofactor required for Sp1 transcriptional activation subunit 8, CRSP complex subunit 8, Mediator complex subunit 27, P37 TRAP/SMCC/PC2 subunit, Transcriptional coactivator CRSP34, MED27, CRSP34 {ECO:0000312|EMBL:AAD127211}, CRSP8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7432c was selected from the Center region of human CRSP8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MED27
Synonyms CRSP34 {ECO:0000312|EMBL:AAD12721.1}, CR
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Cellular Location Nucleus
Research Areas
Citations (0)

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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. CRSP8 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.


Ryu S., Zhou S., Ladurner A.G., Tjian R.Nature 397:446-450(1999) Malik S., Gu W., Wu W.Mol. Cell 5:753-760(2000) Zhang X., Krutchinsky A., Fukuda A.Mol. Cell 19:89-100(2005)

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$ 80.00
Cat# BP7432c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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