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ADAMTS13 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q76LX8
Clone Names 80325124
Peptide ID 80325124
Additional Information
Gene ID 11093
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7438c was selected from the Center region of human ADAMTS13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C9orf8
Function Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
Cellular Location Secreted. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats
Tissue Location Plasma. Expressed primarily in liver.
Research Areas
Citations (0)

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ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.


Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)Levy G.G., Nichols W.C.Nature 413:488-494(2001) Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002) Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)

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$ 80.00
Cat# BP7438c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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