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ADAMTS13 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q76LX8 |
|---|---|
| Clone Names | 80325124 |
| Gene ID | 11093 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7438c was selected from the Center region of human ADAMTS13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS13 |
|---|---|
| Synonyms | C9orf8 |
| Function | Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. |
| Cellular Location | Secreted. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats |
| Tissue Location | Plasma. Expressed primarily in liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
References
Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)Levy G.G., Nichols W.C.Nature 413:488-494(2001) Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002) Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)
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