|Other Names||L-xylulose reductase, XR, Carbonyl reductase II, Dicarbonyl/L-xylulose reductase, Kidney dicarbonyl reductase, kiDCR, Sperm surface protein P34H, DCXR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7443c was selected from the Center region of human DCXR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.|
|Cellular Location||Membrane; Peripheral membrane protein. Note=Probably recruited to membranes via an interaction with phosphatidylinositol.|
|Tissue Location||Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis|
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Provided below are standard protocols that you may find useful for product applications.
DCXR is an enzyme that has both diacetyl reductase and L-xylulose reductase activities.
Nakagawa J., Ishikura S.J. Biol. Chem. 277:17883-17891(2002) Xia X.Y., Xu X.F., Gao Y.Zhonghua Nan Ke Xue 9:24-27(2003)El-Kabbani O., Chung R.P.-T.Acta Crystallogr. D 58:1379-1380(2002)
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