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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SPRY4 Antibody (C-term) Blocking peptide   

SPRY4 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9C004
Clone Names 6072338
Peptide ID 6072338
Additional Information
Gene ID 81848
Other Names Protein sprouty homolog 4, Spry-4, SPRY4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7446b was selected from the Human region of human SPRY4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPRY4
Function Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
Cellular Location Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. The protein is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.


Tsai CF, et al. (2008) J Proteome ResGuo A, et al. (2008) Proc Natl Acad Sci U S A 105, 692-7Rikova K, et al. (2007) Cell 131, 1190-203Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM (2007) Proc Natl Acad Sci U S A 104, 5860-5Tsumura Y, et al. (2005) Biochem J 387, 627-37

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$ 80.00
Cat# BP7446b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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