|Other Names||Cytochrome P450 2J2, Arachidonic acid epoxygenase, CYPIIJ2, CYP2J2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7450a was selected from the N-term region of human CYP2J2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney|
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Provided below are standard protocols that you may find useful for product applications.
CYP2J2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue.
Wu S., Moomaw C.R., Tomer K.B.J. Biol. Chem. 271:3460-3468(1996)King L.M., Ma J., Srettabunjong S.Mol. Pharmacol. 61:840-852(2002)
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