|Other Names||Homeobox protein engrailed-2, Homeobox protein en-2, Hu-En-2, EN2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7457b was selected from the C-term region of human EN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
EN2 is thought to have a role in controlling development. In Drosophila, the protein plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. This protein has been implicated in the control of pattern formation during development of the central nervous system.
Poole S.J., Law M.L.Genomics 4:225-231(1989)Benayed R., Gharani N.Am. J. Hum. Genet. 77:851-868(2005)
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