|Other Names||Insulin-like growth factor-binding protein complex acid labile subunit, ALS, IGFALS, ALS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7478c was selected from the Center region of human IGFALS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.|
|Cellular Location||Secreted, extracellular space.|
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Provided below are standard protocols that you may find useful for product applications.
IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this protein are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty.
Leong S.R., Baxter R.C.Mol. Endocrinol. 6:870-876(1992)Suwanichkul A.Endocrinology 141:833-838(2000) Liu T., Qian W.-J.J. Proteome Res. 4:2070-2080(2005)
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