|Other Names||Regucalcin, RC, Gluconolactonase, GNL, Senescence marker protein 30, SMP-30, RGN, SMP30|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7487c was selected from the Center region of human RGN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
RGN is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. This protein may have an important role in calcium homeostasis. Studies in rat indicate that the protein may also play a role in aging, as it shows age-associated down-regulation.
Ishigami,A., Handa,S. Biosci. Biotechnol. Biochem. 67 (1), 158-160 (2003)Fujita,T., Shirasawa,T. Mech. Ageing Dev. 107 (3), 271-280 (1999)Fujita,T., Mandel,J.L. Biochim. Biophys. Acta 1263 (3), 249-252 (1995)
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