|Other Names||Matrix metalloproteinase-21, MMP-21, 3424-, MMP21|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7497b was selected from the C-term region of human MMP21. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).|
|Tissue Location||Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
MMP21 is a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.
Skoog,T., Elomaa,O. J. Invest. Dermatol. 129 (1), 119-130 (2009)Qiu,W., Zhou,G. Cancer Epidemiol. Biomarkers Prev. 17 (9), 2514-2518 (2008)Bister,V., Skoog,T. Mod. Pathol. 20 (11), 1128-1140 (2007)Skoog,T., Ahokas,K. Exp. Dermatol. 15 (10), 775-783 (2006)
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