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MMP21 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N119
Clone Names 80325165
Peptide ID 80325165
Additional Information
Gene ID 118856
Other Names Matrix metalloproteinase-21, MMP-21, 3424-, MMP21
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7497c was selected from the Center region of human MMP21. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP21
Function Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).
Cellular Location Secreted.
Tissue Location Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines.
Research Areas
Citations (0)

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Background

MMP21 encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.

References

Skoog,T., Elomaa,O. J. Invest. Dermatol. 129 (1), 119-130 (2009)Qiu,W., Zhou,G. Cancer Epidemiol. Biomarkers Prev. 17 (9), 2514-2518 (2008)Bister,V., Skoog,T. Mod. Pathol. 20 (11), 1128-1140 (2007)Skoog,T., Ahokas,K. Exp. Dermatol. 15 (10), 775-783 (2006)

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$ 80.00
Cat# BP7497c
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