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MAK Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P20794
Clone Names 3012008
Peptide ID 3012008
Additional Information
Gene ID 4117
Other Names Serine/threonine-protein kinase MAK, Male germ cell-associated kinase, MAK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7542b was selected from the C-term region of human MAK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAK
Function Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
Tissue Location Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
Research Areas
Citations (0)

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MAK is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.


Xia, L., et al., J. Biol. Chem. 277(38):35422-35433 (2002).Taketo, M., et al., Genomics 19(2):397-398 (1994).Jinno, A., et al., Mol. Cell. Biol. 13(7):4146-4156 (1993).Bladt, F., et al., Differentiation 53(2):115-122 (1993).Koji, T., et al., Cell Biochem. Funct. 10(4):273-279 (1992).

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$ 80.00
Cat# BP7542b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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