|Other Names||Serine/threonine-protein kinase PRP4 homolog, PRP4 kinase, PRP4 pre-mRNA-processing factor 4 homolog, PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7551b was selected from the C-term region of human PRP4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0536, PRP4, PRP4H, PRP4K|
|Function||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.|
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Provided below are standard protocols that you may find useful for product applications.
Pre-mRNA splicing occurs in two sequential transesterification steps, and PRP4 is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).
Dellaire, G., et al., Mol. Cell. Biol. 22(14):5141-5156 (2002).Kojima, T., et al., J. Biol. Chem. 276(34):32247-32256 (2001).Huang, Y., et al., Biochem. Biophys. Res. Commun. 271(2):456-463 (2000).Gross, T., et al., Nucleic Acids Res. 25(5):1028-1035 (1997).
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