|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7555a was selected from the N-term region of human DYRK1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DYRK, MNB, MNBH|
|Function||May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.|
|Cellular Location||Nucleus speckle.|
|Tissue Location||Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.|
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DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Adayev,T., Biochemistry 46 (25), 7614-7624 (2007)Chang,H.S., Int. J. Cancer 120 (11), 2377-2385 (2007)Alvarez,M., Mol. Biol. Cell 18 (4), 1167-1178 (2007)Wissing,J., Mol. Cell Proteomics 6 (3), 537-547 (2007)
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