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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   DYRK1A Antibody (Center) Blocking Peptide   

DYRK1A Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13627
Clone Names 70411256
Peptide ID 70411256
Additional Information
Gene ID 1859
Other Names Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7555c was selected from the Center region of human DYRK1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DYRK, MNB, MNBH
Function May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.
Cellular Location Nucleus speckle.
Tissue Location Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Research Areas
Citations (0)

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DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.


Adayev,T., Biochemistry 46 (25), 7614-7624 (2007)Chang,H.S., Int. J. Cancer 120 (11), 2377-2385 (2007)Alvarez,M., Mol. Biol. Cell 18 (4), 1167-1178 (2007)Wissing,J., Mol. Cell Proteomics 6 (3), 537-547 (2007)

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$ 80.00
Cat# BP7555c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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