Alanyl-tRNA synthetase 2 (AARS2) Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q5JTZ9 |
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Other Accession | A2RRN5 |
Clone Names | 71228104 |
Gene ID | 57505 |
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Other Names | Alanine--tRNA ligase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03133}, 6117 {ECO:0000255|HAMAP-Rule:MF_03133}, Alanyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_03133}, AlaRS {ECO:0000255|HAMAP-Rule:MF_03133}, AARS2 {ECO:0000255|HAMAP-Rule:MF_03133} |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7559b was selected from the C-term region of human AARS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AARS2 {ECO:0000255|HAMAP-Rule:MF_03133} |
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Synonyms | AARSL, KIAA1270 |
Function | Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. |
Cellular Location | Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:21549344} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Alanyl-tRNA synthetase 2 (AARS2) is an enzyme that catalyzes the chemical reaction: ATP + L-alanine + tRNAAla <---> AMP + diphosphate + L-alanyl-tRNAAla.This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis.
References
Bonnefond,L.,Biochemistry 44 (12), 4805-4816 (2005)Nakayama,M., Genome Res. 12 (11), 1773-1784 (2002)
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