|Other Names||Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase, T2, ACAT1, ACAT, MAT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7560b was selected from the C-term region of human ACAT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in ketone body metabolism.|
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Provided below are standard protocols that you may find useful for product applications.
ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder,an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Locke,J.A.,Prostate 68 (1), 20-33 (2008)Guo,Z.Y.,Biochemistry 46 (35), 10063-10071 (2007)Haapalainen,A.M.,Biochemistry 46 (14), 4305-4321 (2007)
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