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PPP1R13B Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96KQ4
Clone Names 71017123
Additional Information
Gene ID 23368
Other Names Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B, PPP1R13B, ASPP1, KIAA0771
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7581a was selected from the N-term region of human PPP1R13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R13B
Synonyms ASPP1, KIAA0771
Function Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear
Tissue Location Reduced expression in breast carcinomas expressing a wild-type TP53 protein
Research Areas
Citations (0)

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Background

PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. This protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.

References

Agirre,X., Oncogene 25 (13), 1862-1870 (2006)Liu,Z.J., Biochim. Biophys. Acta 1756 (1), 77-80 (2005)Bergamaschi,D., Oncogene 24 (23), 3836-3841 (2005)

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$ 80.00
Cat# BP7581a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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