|Other Names||Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B, PPP1R13B, ASPP1, KIAA0771|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7581a was selected from the N-term region of human PPP1R13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear|
|Tissue Location||Reduced expression in breast carcinomas expressing a wild-type TP53 protein|
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Provided below are standard protocols that you may find useful for product applications.
PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. This protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Agirre,X., Oncogene 25 (13), 1862-1870 (2006)Liu,Z.J., Biochim. Biophys. Acta 1756 (1), 77-80 (2005)Bergamaschi,D., Oncogene 24 (23), 3836-3841 (2005)
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