PPP1R13B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96KQ4 |
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Clone Names | 71017123 |
Gene ID | 23368 |
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Other Names | Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B, PPP1R13B, ASPP1, KIAA0771 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7581a was selected from the N-term region of human PPP1R13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PPP1R13B |
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Synonyms | ASPP1, KIAA0771 |
Function | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. |
Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear |
Tissue Location | Reduced expression in breast carcinomas expressing a wild-type TP53 protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PPP1R13B is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. This protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
References
Agirre,X., Oncogene 25 (13), 1862-1870 (2006)Liu,Z.J., Biochim. Biophys. Acta 1756 (1), 77-80 (2005)Bergamaschi,D., Oncogene 24 (23), 3836-3841 (2005)
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