|Other Names||Complement C1r subcomponent-like protein, C1r-LP, C1r-like protein, 3421-, C1r-like serine protease analog protein, CLSPa, C1RL, C1RL1, C1RLP, CLSPA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7603a was selected from the N-term region of human C1RL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C1RL1, C1RLP, CLSPA|
|Function||Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.|
|Tissue Location||Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV- 3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
C1RL mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
Lin,N., Liu,S. Biochem. Biophys. Res. Commun. 321 (2), 329-336 (2004)Wicher,K.B. Proc. Natl. Acad. Sci. U.S.A. 101 (40), 14390-14395 (2004)Cerhan,J.R., Novak,A.J. Br. J. Haematol. (2009) In press
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