PCSK2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P16519 |
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Clone Names | 80917124 |
Gene ID | 5126 |
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Other Names | Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2, PCSK2, NEC2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7617a was selected from the N-term region of human PCSK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PCSK2 |
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Synonyms | NEC2 |
Function | Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules |
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Provided below are standard protocols that you may find useful for product applications.
Background
PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
References
Leak,T.S., Keene,K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007)Shen,X., Li,Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005)Tzimas,G.N., Chevet,E. BMC Cancer 5, 149 (2005)Seidah,N.G., Mattei,M.G. Genomics 11 (1), 103-107 (1991)
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