|Other Names||Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2, PCSK2, NEC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7617a was selected from the N-term region of human PCSK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules|
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Provided below are standard protocols that you may find useful for product applications.
PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
Leak,T.S., Keene,K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007)Shen,X., Li,Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005)Tzimas,G.N., Chevet,E. BMC Cancer 5, 149 (2005)Seidah,N.G., Mattei,M.G. Genomics 11 (1), 103-107 (1991)
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