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XPOT Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43592
Clone Names 80924291
Peptide ID 80924291
Additional Information
Gene ID 11260
Other Names Exportin-T, Exportin(tRNA), tRNA exportin, XPOT
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7632b was selected from the C-term region of human XPOT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm Shuttles between the nucleus and the cytoplasm
Research Areas
Citations (0)

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XPOT is a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.


Li,S. , RNA Biol 3 (4), 145-149 (2006)Suzuki,T., Biomed. Res. 27 (2), 89-92 (2006)Kuersten,S., Mol. Cell. Biol. 22 (16), 5708-5720 (2002)

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$ 80.00
Cat# BP7632b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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