DOK6 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6PKX4 |
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Gene ID | 220164 |
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Other Names | Docking protein 6, Downstream of tyrosine kinase 6, DOK6, DOK5L |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7659a was selected from the Center region of human DOK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DOK6 |
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Synonyms | DOK5L |
Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. |
Tissue Location | Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK6, a member of the p62 Dok family of intracellular adaptor molecules, promotes Ret-mediated neurite growth, and may have a role in brain development and/or maintainance Dok-6 is abundantly expressed in the fetal and adult brain and cerebellum, and is co-expressed with Ret in sympathetic, sensory, and parasympathetic ganglia, and in the ureteric buds of the developing kidneys. DOK6 Interacts via its PTB domain with phosphorylated RET through an Src-dependent mechanism, indicating that DOK6 is a substrate of the Ret-Src signaling pathway.
References
Crowder, R.J., et al., J. Biol. Chem. 279(40):42072-42081 (2004).
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