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DOK6 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6PKX4
Additional Information
Gene ID 220164
Other Names Docking protein 6, Downstream of tyrosine kinase 6, DOK6, DOK5L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7659a was selected from the Center region of human DOK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK6
Synonyms DOK5L
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance.
Tissue Location Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
Research Areas
Citations (0)

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Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK6, a member of the p62 Dok family of intracellular adaptor molecules, promotes Ret-mediated neurite growth, and may have a role in brain development and/or maintainance Dok-6 is abundantly expressed in the fetal and adult brain and cerebellum, and is co-expressed with Ret in sympathetic, sensory, and parasympathetic ganglia, and in the ureteric buds of the developing kidneys. DOK6 Interacts via its PTB domain with phosphorylated RET through an Src-dependent mechanism, indicating that DOK6 is a substrate of the Ret-Src signaling pathway.


Crowder, R.J., et al., J. Biol. Chem. 279(40):42072-42081 (2004).

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$ 80.00
Cat# BP7659a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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