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TRIB1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96RU8
Clone Names 6030104
Peptide ID 6030104
Additional Information
Gene ID 10221
Other Names Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, GIG-2, SKIP1, TRIB1 (HGNC:16891)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7726b was selected from the C-term region of human TRIB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIB1 (HGNC:16891)
Function Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.
Tissue Location Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow
Research Areas
Citations (0)

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TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities.Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.


Kiss-Toth, E., et al., J. Biol. Chem. 279(41):42703-42708 (2004).Wu, M., et al., J. Biol. Chem. 278(29):27072-27079 (2003).Wilkin, F., et al., Eur. J. Biochem. 248(3):660-668 (1997).

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$ 80.00
Cat# BP7726b
Availability: In Stock
Bulk Size
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