|Other Names||Sodium/nucleoside cotransporter 2, Concentrative nucleoside transporter 2, CNT 2, rCNT2, Na(+)/nucleoside cotransporter 2, Sodium-coupled nucleoside transporter 2, Sodium/purine nucleoside cotransporter, SPNT, Solute carrier family 28 member 2, Slc28a2, Cnt2, Spnt|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7738c was selected from the Center region of human SLC28A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in liver (in bile canalicular membrane vesicles (CMV) but not in sinusoidal vesicles), jejunum, spleen and heart. Also expressed in brain and skeletal muscle. Not expressed in kidney, muscle and lung|
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Provided below are standard protocols that you may find useful for product applications.
SLC28A2 regulates adenosine transport across the blood-brain barrier into the brain.
Li,L., Pharmacogenet. Genomics 17 (9), 783-786 (2007)
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