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IPF Antibody (S66) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP7740e | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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IPF Antibody (S66) Blocking Peptide - Product info | |
| Primary Accession | P52945 |
| Clone Names | 80130216 |
| Calculated MW | 30771 Da |
IPF Antibody (S66) Blocking Peptide - Additional info | |
| Gene ID 3651 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7740e was selected from the S66 region of human IPF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
IPF Antibody (S66) Blocking Peptide - Protein Information | |
| Name PDX1 | |
| Synonyms IPF1, STF1 | |
| Function Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3' During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell | |
| Cellular Location Nucleus. Cytoplasm, cytosol (By similarity). | |
| Tissue Location Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells) | |
IPF Antibody (S66) Blocking Peptide - Related products
AP3617a: Phospho-IPF-pT11 Antibody
AP3618a: Phospho-IPF-pS66 Antibody
AP3669a: Phospho-PDX1-T11 Antibody
AP7740a: PDX1 Antibody (N-term)
AP7740b: IPF Antibody (C-term)
BP3617a: Phospho-IPF-pT11 Antibody Blocking Peptide
BP3618a: Phospho-IPF-pS66 Antibody Blocking Peptide
BP3669a: Phospho-PDX1-T11 Antibody Blocking Peptide
BP7740a: IPF Antibody (N-term) Blocking Peptide
BP7740b: IPF Antibody (C-term) Blocking Peptide
IPF Antibody (S66) Blocking Peptide - Research Areas
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BACKGROUND
IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
REFERENCES
Ma,J., Carcinogenesis 29 (7), 1327-1333 (2008)Watada,H., Biochem. Biophys. Res. Commun. 229 (3), 746-751 (1996)
