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APS Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O14492
Clone Names 80220136
Peptide ID 80220136
Additional Information
Gene ID 10603
Other Names SH2B adapter protein 2, Adapter protein with pleckstrin homology and Src homology 2 domains, SH2 and PH domain-containing adapter protein APS, SH2B2, APS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7747c was selected from the Center region of human APS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH2B2
Synonyms APS
Function Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.
Cellular Location Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region
Tissue Location Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines.
Research Areas
Citations (0)

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APS is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.


Li,M., Endocrinology 148 (4), 1615-1621 (2007)Katsanakis,K.D., J. Biol. Chem. 280 (45), 37827-37832 (2005)Iseki,M., Biochem. Biophys. Res. Commun. 330 (3), 1005-1013 (2005)

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$ 80.00
Cat# BP7747c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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