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MDK Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P21741
Other Accession NP_002382
Clone Names 71211132
Additional Information
Gene ID 4192
Other Names Midkine, MK, Amphiregulin-associated protein, ARAP, Midgestation and kidney protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, MDK, MK1, NEGF2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7781a was selected from the N-term region of human MDK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MDK
Synonyms MK1, NEGF2
Function Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions
Research Areas
Citations (0)

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MDK has heparin binding activity and growth promoting activity. It is involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment and also involved in early fetal adrenal gland development.


Huang,Y., Biochem. Biophys. Res. Commun. 377 (2), 474-478 (2008)Ikematsu,S., Cancer Sci. 99 (10), 2070-2074 (2008)Ota,K., Br. J. Cancer 99 (4), 655-662 (2008)

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$ 80.00
Cat# BP7781a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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