|Other Names||Scrapie-responsive protein 1, Scrapie-responsive gene 1 protein, ScRG-1, SCRG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7784c was selected from the Center region of human SCRG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta|
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Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus.
Hu,Y., Mol. Cell Proteomics 4 (12), 2000-2009 (2005)Clark,H.F., Genome Res. 13 (10), 2265-2270 (2003)Dron,M., J. Biol. Chem. 273 (29), 18015-18018 (1998)
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