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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   LIM Kinase 2 (LIMK2) Antibody (N-term) Blocking peptide   

LIM Kinase 2 (LIMK2) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P53671
Other Accession P53667
Clone Names 2121809
Peptide ID 2121809
Additional Information
Gene ID 3985
Other Names LIM domain kinase 2, LIMK-2, LIMK2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7815a was selected from the N-term region of human LIMK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIMK2
Function Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Cellular Location Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus
Tissue Location Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form In adult lung, both LIMK2a and LIMK2b is nearly equally observed
Research Areas
Citations (0)

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There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The LIMK2 protein is phosphorylated and activated by ROCK, a downstream effector of Rho, and LIM kinase 2, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. Two alternative splice variants of LIMK2 that utilize alternative promoters have been identified.


Nomoto, S., et al., Gene 236(2):259-271 (1999).Osada, H., et al., Biochem. Biophys. Res. Commun. 229(2):582-589 (1996).Okano, I., et al., J. Biol. Chem. 270(52):31321-31330 (1995).

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$ 80.00
Cat# BP7815a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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