|Other Names||Histone acetyltransferase KAT6B, Histone acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, MYST-4, Monocytic leukemia zinc finger protein-related factor, KAT6B, KIAA0383, MORF, MOZ2, MYST4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7828b was selected from the C-term region of human MORF/MYST4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0383, MORF, MOZ2, MYST4|
|Function||Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|
|Tissue Location||Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.|
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MORF/MYST4 is a histone acetyltransferase which may be involved in both positive and negative regulation of transcription. It is required for RUNX2-dependent transcriptional activation and may be involved in cerebral cortex development.
Pena,A.N., Ann. N. Y. Acad. Sci. 1100, 299-305 (2007)Olsen,J.V., Cell 127 (3), 635-648 (2006)Liu,C., Cytokine 27 (4-5), 93-100 (2004)
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