|Other Names||Tyrosine--tRNA ligase, mitochondrial, Tyrosyl-tRNA synthetase, TyrRS, YARS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7838b was selected from the C-term region of human YARS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr).|
|Cellular Location||Mitochondrion matrix|
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Provided below are standard protocols that you may find useful for product applications.
YARS2 catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Bonnefond,L., Structure 15 (11), 1505-1516 (2007)Bonnefond,L., RNA 11 (5), 558-562 (2005)Bonnefond,L., Biochemistry 44 (12), 4805-4816 (2005)
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