|Other Names||Microsomal glutathione S-transferase 3, Microsomal GST-3, Microsomal GST-III, MGST3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7855a was selected from the N-term region of human MGST3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Also functions as a glutathione peroxidase.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein. Microsome membrane; Lipid-anchor|
|Tissue Location||Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. MGST3 is an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.
Thameem,F., Hum. Genet. 113 (4), 353-358 (2003)Jakobsson,P.J., Am. J. Respir. Crit. Care Med. 161 (2 PT 2), S20-S24 (2000)
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