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PK3CA Antibody (Y317) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP7860a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
PK3CA Antibody (Y317) Blocking Peptide - Product info | |
| Primary Accession | P42336 |
| Clone Names | 80220120 |
| Calculated MW | 124284 Da |
PK3CA Antibody (Y317) Blocking Peptide - Additional info | |
| Gene ID 5290 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7860a was selected from the Y317 region of human PK3CA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
PK3CA Antibody (Y317) Blocking Peptide - Protein Information | |
| Name PIK3CA | |
| Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS | |
PK3CA Antibody (Y317) Blocking Peptide - Related products
AP8016c: PI3KCA Antibody (Center)
AP3558a: Phospho-PK3CA-pY317 Antibody
AP7860a: PK3CA Antibody (Y317)
AP8016a: PI3KCA Antibody (N-term)
AP8016b: PI3KCA Antibody (C-term)
RI13994: PIK3CA predesign siRNA
BP3558a: Phospho-PK3CA-pY317 Antibody Blocking Peptide
BP7860a: PK3CA Antibody (Y317) Blocking Peptide
BP8016a: PI3KCA Antibody (N-term) Blocking Peptide
BP8016b: PI3KCA Antibody (C-term) Blocking Peptide
BP8016c: PI3KCA Antibody (Center) Blocking Peptide
PK3CA Antibody (Y317) Blocking Peptide - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. This protein represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2.
REFERENCES
Zhao,L., Oncogene 27 (41), 5486-5496 (2008)Volinia,S., Genomics 24 (3), 472-477 (1994)Hiles,I.D., Cell 70 (3), 419-429 (1992)
