|Other Names||Mitogen-activated protein kinase kinase kinase 6, Apoptosis signal-regulating kinase 2, MAP3K6, ASK2, MAPKKK6, MEKK6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7912a was selected from the C-term region of human MEKK6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASK2, MAPKKK6, MEKK6|
|Function||Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.|
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Provided below are standard protocols that you may find useful for product applications.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK6 activates the JNK, but not ERK or p38 kinase pathways.
Wang, X.S., et al., Biochem. Biophys. Res. Commun. 253(1):33-37 (1998).
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