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MKK3 Antibody (S189) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P46734
Clone Names 1112606
Peptide ID 1112606
Additional Information
Gene ID 5606
Other Names Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7915d was selected from the S189 region of human MKK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP2K3
Synonyms MEK3, MKK3, PRKMK3, SKK2
Function Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Tissue Location Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues
Research Areas
Citations (0)

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MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.


Demuth,T.,Mol. Cancer Ther. 6 (4), 1212-1222 (2007)Prickett,T.D.,Mol. Cell. Biol. 27 (12), 4217-4227 (2007)Stein,B.,J. Biol. Chem. 271 (19), 11427-11433 (1996)

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$ 80.00
Cat# BP7915d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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