|Other Names||Mitogen-activated protein kinase kinase kinase 10, Mixed lineage kinase 2, Protein kinase MST, MAP3K10, MLK2, MST|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7920a was selected from the C-term region of human MLK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activates the JUN N-terminal pathway.|
|Tissue Location||Expressed in brain and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can bephoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Dorow, D.S., et al., Eur. J. Biochem. 234(2):492-500 (1995).Katoh, M., et al., Oncogene 10(7):1447-1451 (1995).Dorow, D.S., et al., Eur. J. Biochem. 213(2):701-710 (1993).
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