|Other Names||Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7947b was selected from the C-term region of human SGK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in liver, kidney and pancreas, and at lower levels in brain|
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Provided below are standard protocols that you may find useful for product applications.
SGK2, a Ser/Thr protein kinase, is similar to serum- and glucocorticoid-induced protein kinase (SGK), but this gene product is not induced by serum or glucocorticoids. Expression is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
Friedrich, B., et al., Pflugers Arch. 445(6):693-696 (2003).Embark, H.M., et al., Pflugers Arch. 445(5):601-606 (2003).Gamper, N., et al., Pflugers Arch. 445(1):60-66 (2002).Lang, F., et al., Sci. STKE 2001 (108), RE17 (2001).Kobayashi, T., et al., Biochem. J. 344 Pt 1, 189-197 (1999).
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