|Other Names||Phosphoinositide 3-kinase regulatory subunit 5, PI3-kinase regulatory subunit 5, PI3-kinase p101 subunit, Phosphatidylinositol 4, 5-bisphosphate 3-kinase regulatory subunit, PtdIns-3-kinase regulatory subunit, Protein FOAP-2, PtdIns-3-kinase p101, p101-PI3K, PIK3R5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8027c was selected from the Center region of human PI3KR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.|
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Provided below are standard protocols that you may find useful for product applications.
PI3KR5 is a regulatory subunit of the PI3K gamma complex. This protein, which interacts with G beta gamma proteins, is a heterodimer of a catalytic subunit (PI3KCG/p120) and a regulatory (PI3KR5a/p101) subunit.
Brock, C., et al., J. Cell Biol. 160(1):89-99 (2003).
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