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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PI 4 Kinase type 2 beta antibody (N-term) Blocking peptide   

PI 4 Kinase type 2 beta antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8TCG2
Other Accession NP_060793
Clone Names 2071001
Peptide ID 2071001
Additional Information
Gene ID 55300
Other Names Phosphatidylinositol 4-kinase type 2-beta, Phosphatidylinositol 4-kinase type II-beta, PI4KII-BETA, PI4K2B
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8033a was selected from the N-term region of human PI4K II beta . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PI4K2B
Function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Cellular Location Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein.By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.


Wei, Y.J., et al., J. Biol. Chem. 277(48):46586-46593 (2002).Mora, S., et al., J. Biol. Chem. 277(30):27494-27500 (2002).Balla, A., et al., J. Biol. Chem. 277(22):20041-20050 (2002).

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$ 80.00
Cat# BP8033a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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