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SMG1 Antibody (C-term C3637) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96Q15
Clone Names 4112803
Peptide ID 4112803
Additional Information
Gene ID 23049
Other Names Serine/threonine-protein kinase SMG1, SMG-1, hSMG-1, Lambda/iota protein kinase C-interacting protein, Lambda-interacting protein, SMG1, ATX, KIAA0421, LIP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8055e was selected from the C-term region of human SMG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMG1
Synonyms ATX, KIAA0421, LIP
Function Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver.
Research Areas
Citations (0)

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This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.


DNA Repair (Amst.) 3 (8-9), 919-925 (2004)Mol. Cell 14 (5), 585-598 (2004)Genes Dev. 15 (17), 2215-2228 (2001)J. Biol. Chem. 276 (25), 22709-22714 (2001)

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$ 80.00
Cat# BP8055e
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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