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NEK3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P51956
Other Accession NP_002489
Clone Names 2121609
Additional Information
Gene ID 4752
Other Names Serine/threonine-protein kinase Nek3, HSPK 36, Never in mitosis A-related kinase 3, NimA-related protein kinase 3, NEK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8075c was selected from the Center region of human NEK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEK3
Function Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
Cellular Location Cytoplasm. Cell projection, axon
Tissue Location Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
Research Areas
Citations (0)

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In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. NEK3 is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm.


Schultz, S.J., et al., Cell Growth Differ. 5(6):625-635 (1994).Schultz, S.J., et al., Cell Growth Differ. 4(10):821-830 (1993).Kimura, M., et al., Cytogenet. Cell Genet. 95 (3-4), 177-182 (2001).

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$ 80.00
Cat# BP8075c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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