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NEK9 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TD19
Clone Names 2121801
Peptide ID 2121801
Additional Information
Gene ID 91754
Other Names Serine/threonine-protein kinase Nek9, Nercc1 kinase, Never in mitosis A-related kinase 9, NimA-related protein kinase 9, NimA-related kinase 8, Nek8, NEK9, KIAA1995, NEK8, NERCC
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8079b was selected from the C-term region of human NEK9 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEK9
Synonyms KIAA1995, NEK8, NERCC
Function Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
Cellular Location Cytoplasm. Nucleus
Tissue Location Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts
Research Areas
Citations (0)

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NEK9, a member of the NIMA subfamily of Ser/Thr protein kinases, is a pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. It phosphorylates different histones (serine and threonine residues on H3), myelin basic protein, beta-casein (serine residues), and BICD2. NEK9 is activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions, and is sensitive to increasing concentration of detergents. This protein is not cell-cycle regulated but activity is higher in G0-arrested cells. NEK is part of a homodimer that binds to Ran GTPase, and exhibits a greater affinity for Ran-GDP over Ran-GTP. Interaction is also noted with NEK6 and NEK7 family members. This cytoplasmic protein is most abundant in heart, liver, kidney and testis, and is also expressed in smooth muscle cells and fibroblasts. Expression varies mildly across the cell cycle, with highest expression observed in G1 and stationary-phase cells.


Tan,B.C. et al. J. Biol. Chem. 279 (10), 9321-9330 (2004) Belham,C. et al. J. Biol. Chem. 278 (37), 34897-34909 (2003) Roig, J. et al. Genes Dev. 16(13):1640-1658 (2002). Holland, P.M. et al. J. Biol. Chem. 277(18):16229-16240 (2002). Strausberg, R.L. et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).

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$ 80.00
Cat# BP8079b
(40 western blots)
Availability: In Stock
Bulk Size
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