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NME2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P22392
Clone Names 3040705
Peptide ID 3040705
Additional Information
Gene ID 4831;654364
Other Names Nucleoside diphosphate kinase B, NDK B, NDP kinase B, C-myc purine-binding transcription factor PUF, Histidine protein kinase NDKB, nm23-H2, NME2, NM23B
Target/Specificity The synthetic peptide sequence is selected from aa 40~54 of human NME2.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NME2
Synonyms NM23B
Function Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Cellular Location Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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NM23 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in skeletal muscle, and negligible expression in other mouse tissues examined.


Munier, A., et al., Exp. Cell Res. 289(2):295-306 (2003).Kim, S.H., et al., Biochem. Biophys. Res. Commun. 296(4):970-975 (2002).Okabe-Kado, J., et al., Leuk. Res. 26(6):569-576 (2002).Godfried, M.B., et al., Oncogene 21(13):2097-2101 (2002).Postel, E.H., et al., Biochemistry 41(20):6330-6337 (2002).

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$ 80.00
Cat# BP8081a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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