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ULK3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q6PHR2
Clone Names 70411248
Peptide ID 70411248
Additional Information
Gene ID 25989
Other Names Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3, ULK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8115a was selected from the N-term region of human ULK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ULK3
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Cellular Location Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
Tissue Location Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord
Research Areas
Citations (0)

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ULK3 is a member of the ULK kinase family, one of three human homologs of the yeast autophagy-specific kinase.


The MGC Project Team, Genome Res. 14:2121-2127(2004).

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$ 80.00
Cat# BP8115a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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