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GCKR Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14397
Clone Names 3051209
Peptide ID 3051209
Additional Information
Gene ID 2646
Other Names Glucokinase regulatory protein, GKRP, Glucokinase regulator, GCKR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8143b was selected from the C-term region of human GCKR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Cellular Location Cytoplasm. Nucleus. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus
Tissue Location Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
Research Areas
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GCKR belongs to the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. Th GCKR gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).


Veiga-da-Cunha, M., et al., Diabetologia 46(5):704-711 (2003).Hayward, B.E., et al., Genomics 49(1):137-142 (1998).Hayward, B.E., et al., Mamm. Genome 7(6):454-458 (1996).Warner, J.P., et al., Mamm. Genome 6(8):532-536 (1995).Vaxillaire, M., et al., Diabetes 43(3):389-395 (1994).

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$ 80.00
Cat# BP8143b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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