|Other Names||Guanylate cyclase soluble subunit alpha-2, GCS-alpha-2, GUCY1A2, GUC1A2, GUCSA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8176b was selected from the C-term region of human GUCY1A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has guanylyl cyclase on binding to the beta-1 subunit.|
|Tissue Location||Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium|
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Provided below are standard protocols that you may find useful for product applications.
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
Baba, H., et al., Neuroreport 15(4):677-680 (2004).Bellamy, T.C., et al., Proc. Natl. Acad. Sci. U.S.A. 99(1):507-510 (2002).Russwurm, M., et al., J. Biol. Chem. 276(48):44647-44652 (2001).Bamberger, A.M., et al., J. Clin. Endocrinol. Metab. 86(2):909-912 (2001).Budworth, J., et al., Biochem. Biophys. Res. Commun. 263(3):696-701 (1999).
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