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BDP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q99952
Clone Names 1112912
Peptide ID 1112912
Additional Information
Gene ID 26469
Other Names Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8401a was selected from the N-term region of human BDP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN18
Synonyms BDP1
Function Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed in brain, colon and several tumor- derived cell lines.
Research Areas
Citations (0)

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Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ? it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.


Kim, Y.W., et al., Oncogene 13(10):2275-2279 (1996).

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$ 80.00
Cat# BP8401a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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